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Isoflurane vs Sevoflurane

What each one is for, how to take it, side effects and warnings, side by side from the official labels.

IsofluraneSevoflurane
What it isGeneral AnestheticGeneral Anesthetic
Used forIsoflurane USP may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia. Isoflurane USP, a general anesthetic, is an inhalation agent indicated for induction a…Sevoflurane, USP is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. Sevoflurane, USP should be administered only by persons trained in the administration of general anesthesia.…
Usual adult doseNot on the labelIt is suitable for mask induction in pediatrics and adults.
Children
Prescription (U.S.)YesYes
Common side effectsMost common adverse reactions (incidence > 5%) are agitation, cough, breath holding, nausea, chills/shivering, vomiting, laryngospasm, delirium. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Piramal Critical Care, Inc. at…Clinical Trials Experience Adverse events are derived from controlled clinical studies conducted in the United States, Canada, and Europe. The reference drugs were isoflurane, enflurane, and propofol in adults and halothane in ped…
Pregnancy8.1 Pregnancy Risk Summary There are no adequate and well-controlled studies in pregnant women. In animal reproduction studies, embryofetal toxicity was noted in pregnant mice exposed to 0.075% (incre…Pregnancy Risk Summary There are no adequate and well-controlled studies in pregnant women. In animal reproduction studies, reduced fetal weights were noted following exposure to 1 MAC sevoflurane for…

From the official U.S. labels. Brands and strengths differ between countries.

Can you take them together?

Neither official label mentions the other. That does not prove they are safe together: ask a pharmacist, and use the free interaction checker.

Check them together

Questions

What is the difference between Isoflurane and Sevoflurane?

Isoflurane is general Anesthetic and Sevoflurane is general Anesthetic. Isoflurane is used for: Isoflurane USP may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia. Isoflurane USP, a general anesthetic, is an inhalation agent indicated for induction a… Sevoflurane is used for: Sevoflurane, USP is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. Sevoflurane, USP should be administered only by persons trained in the administration of general anesthesia.…

Can I take Isoflurane and Sevoflurane together?

Neither official label mentions the other. That does not prove they are safe together: ask a pharmacist, and use the free interaction checker.

Which is better, Isoflurane or Sevoflurane?

It depends on what you are treating, your health and other medicines. Your doctor or pharmacist can tell you which one suits you; this page shows what each official label says.