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Guaifenesin and pseudoephedrine

• helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive • tem.

Checked against the official label · Updated

Sold without prescription in some countries Oral

Guaifenesin and pseudoephedrine: quick answers

Used for
Helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Usual adult dose
Adults and children 12 years and older: 1 extended-release tablet every 12 hours.
Children
Children under 12 years of age: do not use.
Prescription
Sold without prescription in the United States; rules differ by country.

From the official label (May 2026). Your prescription and pharmacist come first.

How to use Guaifenesin and pseudoephedrine

What the official label says. If a doctor prescribed it, follow the prescription. Your pack's leaflet comes first if it is different.

Who it is for

• helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive • temporarily relieves nasal congestion due to: • common cold • hay fever • upper respiratory allergies • temporarily restores freer breathing through the nose • promotes nasal and/or sinus drainage • temporarily relieves sinus congestion and pressure

How to take it and how often

• do not crush, chew, or break extended-release tablet • take with a full glass of water • this product can be administered without regard for timing of meals • adults and children 12 years and older: 1 extended-release tablet every 12 hours; not more than 2 extended-release tablets in 24 hours • children under 12 years of age: do not use

While you are taking it

• do not use more than directed

Talk to a doctor first if

• heart disease • high blood pressure • thyroid disease • diabetes • trouble urinating due to an enlarged prostate gland • persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema • cough accompanied by too much phlegm (mucus)

Warnings

Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have • heart disease • high blood pressure • thyroid disease • diabetes • trouble urinating due to an enlarged prostate gland • persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema • cough accompanied by too much phlegm (mucus) When using this product • do not use more than directed S …

Possible side effects

• you get nervous, dizzy, or sleepless • symptoms do not get better within 7 days, come back or occur with a fever, rash, or persistent headache. These could be signs of a serious illness.

Pregnancy and breastfeeding

If pregnant or breast-feeding, ask a health professional before use.

How to store it

Keep out of reach of children.

If you miss a dose

Take it when you remember, unless it is nearly time for the next dose. Then skip the missed one. Never take two doses at once to make up for it. Check your leaflet, as some medicines are different.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2026-05-26.

Brands around the world

Products with Guaifenesin and pseudoephedrine as the active ingredient. Names differ between countries.

Registered products

United States (FDA)

Guaifenesin And Pseudoephedrine HclGUAIFENESIN 600 mg/1, PSEUDOEPHEDRINE HYDROCHLORIDE 60 mg/1 · Tablet, Extended Release · Aurohealth LLC
NDC 58602-833Label
Guaifenesin And Pseudoephedrine HclGUAIFENESIN 1200 mg/1, PSEUDOEPHEDRINE HYDROCHLORIDE 120 mg/1 · Tablet, Extended Release · Aurohealth LLC
NDC 58602-834Label
Rugby Mucus Relief DGUAIFENESIN 600 mg/1, PSEUDOEPHEDRINE HYDROCHLORIDE 60 mg/1 · Tablet, Multilayer, Extended Release · Rugby Laboratories
NDC 0536-1449Label
Maximum Strength Mucus DGUAIFENESIN 1200 mg/1, PSEUDOEPHEDRINE HYDROCHLORIDE 120 mg/1 · Tablet, Extended Release · CVS Pharmacy
NDC 51316-970Label
Guaifenesin And Pseudoephedrine HclGUAIFENESIN 600 mg/1, PSEUDOEPHEDRINE HYDROCHLORIDE 60 mg/1 · Tablet, Extended Release · Meijer
NDC 79481-1002Label

Other countries: check your pack's registration number and we point you to your regulator.

Check your pack of Guaifenesin and pseudoephedrine

Type the registration number on the pack, or scan it with your camera.

Or take photos of the pack
3 free checks left today Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Guaifenesin and pseudoephedrine

What is Guaifenesin and pseudoephedrine used for?

• helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive • temporarily relieves nasal congestion due to: • common cold • hay fever • upper respiratory allergies • temporarily restores freer breathing through the nose • promotes nasal and/or sinus drainage • temporarily relieves sinus congestion and pressure (From the official U.S. FDA label.)

How do I take Guaifenesin and pseudoephedrine?

Follow your prescription or the leaflet in your pack. The official label says: • do not crush, chew, or break extended-release tablet • take with a full glass of water • this product can be administered without regard for timing of meals • adults and children 12 years and older: 1 extended-release tablet every 12 hours; not more than 2 extended-release tablets in 24 hours • children under 12 years of age: do not use…

Do I need a prescription for Guaifenesin and pseudoephedrine?

In many countries Guaifenesin and pseudoephedrine is sold without a prescription in some strengths. Rules differ by country, so ask a pharmacist.

What brands contain Guaifenesin and pseudoephedrine?

Guaifenesin and pseudoephedrine is sold under names such as Leader Mucus Relief D. Brand names differ between countries.

What are the side effects of Guaifenesin and pseudoephedrine?

The official label lists: • you get nervous, dizzy, or sleepless • symptoms do not get better within 7 days, come back or occur with a fever, rash, or persistent headache. These could be signs of a serious illness. Tell your doctor about any side effect that bothers you or does not go away.

Can children take Guaifenesin and pseudoephedrine?

The label gives a separate dose by age: children 12 years. Check the pack or ask a pharmacist.

Can I take Guaifenesin and pseudoephedrine when pregnant or breastfeeding?

If pregnant or breast-feeding, ask a health professional before use. Ask your doctor or midwife first.

How can I check that my Guaifenesin and pseudoephedrine is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.