Triamcinolone acetonide

Triamcinolone Acetonide Ointment is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

• Apply a thin film of Triamcinolone Acetonide Ointment 0.025% to the affected area two to four times daily
• Apply a thin film of the 0.1% or the 0.5% Triamcinolone Acetonide Ointment, as appropriate, to the affected area two to three times daily
• Occlusive Dressing Technique Occlusive dressings may be used for the management of psoriasis or other recalcitrant conditions
• Apply a thin film of ointment to the lesion, cover with a pliable nonporous film, and seal the edges
• If needed, additional moisture may be provided by covering the lesion with a dampened clean cotton cloth before the nonporous film is applied or by briefly wetting the affected area with water immediately prior to applying the medication
• The frequency of changing dressings is best determined on an individual basis
• It may be convenient to apply Triamcinolone Acetonide Ointment under an occlusive dressing in the evening and to remove the dressing in the morning (i.e., 12-hour occlusion)
• When utilizing the 12-hour occlusion regimen, additional ointment should be applied, without occlusion, during the day
• Reapplication is essential at each dressing change
• If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted

• Pediatric patients may demonstrate greater susceptibility to topical corticosteroid induced HPA axis suppression and Cushing’s syndrome than mature patients because of a larger skin surface area to body weight ratio
• HPA axis suppression, Cushing’s syndrome and intracranial hypertension have been reported in children receiving topical corticosteroids
• Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. …

• Information for the Patient Patients using topical corticosteroids should receive the following information and instructions: 1
• This medication is to be used as directed by the physician
• It is for external use only
• Avoid contact with the eyes. 2
• Patients should be advised not to use this medication for any disorder other than for which it was prescribed. 3
• The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician. 4
• Patients should report any signs of local adverse reactions especially under occlusive dressing. 5. …

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.

PRECAUTIONS General Systemic absorption of topical corticosteroids has produced reversible hypothalamic pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients. Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. …

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings (reactions are listed in an approximate decreasing order of occurrence): burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

Pregnancy: Teratogenic Effects Category C. Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on the teratogenic effects from topically applied corticosteroids. …

Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS, General ).

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