What each one is for, how to take it, side effects and warnings, side by side from the official labels.
| Spironolactone | Eplerenone | |
|---|---|---|
| What it is | Aldosterone Antagonist | Aldosterone Antagonist |
| Used for | Spironolactone tablets are an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure ( 1.1 ). Use as… | is an aldosterone antagonist indicated for: • Improving survival of stable adult patients with symptomatic heart failure with reduced ejection fraction (HFrEF) after an acute myocardial infarction. ( 1.1 ) • The treatment of hypertension in adults, to lower bl… |
| Children | Dose Adjustment in Heart Failure Post-MI Serum Potassium (mEq/L) Dose Adjustment The safety and effectiveness of INSPRA for treatment of hypertension have not been established in pediatric patients. | |
| Prescription (U.S.) | Yes | Yes |
| Common side effects | The following clinically significant adverse reactions are described elsewhere in the labeling: Hyperkalemia [ see Warnings and Precautions (5.1) ] Hypotension and Worsening Renal Function [ see Warnings and Precautions (5.2) ] El… | The following adverse reactions are discussed in greater detail in other sections of the labeling: • Hyperkalemia [see Warnings and Precautions (5.1) ] HFrEF Post-MI: Most common adverse reactions (>2% and more frequent than with… |
| Pregnancy | 8.1 Pregnancy Risk Summary Based on mechanism of action and findings in animal studies, spironolactone may affect sex differentiation of the male during embryogenesis (see Data) . Rat embryofetal stud… | 8.1 Pregnancy Risk Summary The available data from published case reports on eplerenone use during pregnancy are insufficient to establish a drug-associated risk of major birth defects, miscarriage, a… |
From the official U.S. labels. Brands and strengths differ between countries.
Spironolactone is aldosterone Antagonist and Eplerenone is aldosterone Antagonist. Spironolactone is used for: Spironolactone tablets are an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure ( 1.1 ). Use as… Eplerenone is used for: is an aldosterone antagonist indicated for: • Improving survival of stable adult patients with symptomatic heart failure with reduced ejection fraction (HFrEF) after an acute myocardial infarction. ( 1.1 ) • The treatment of hypertension in adults, to lower bl…
It depends on what you are treating, your health and other medicines. Your doctor or pharmacist can tell you which one suits you; this page shows what each official label says.