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Chlorzoxazone

INDICATIONS Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute.

Prescription medicine Oral Safety alerts on record

How to use Chlorzoxazone

Ce que dit la notice officielle. Si un médecin vous l'a prescrit, suivez l'ordonnance. La notice de votre boîte prime si elle est différente.

Pour qui

INDICATIONS Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.

Comment le prendre et à quelle fréquence
  • Usual Adult Dosage One tablet three or four times daily
  • If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily
  • As improvement occurs dosage can usually be reduced
Talk to a doctor first if

Chlorzoxazone is contraindicated in patients with known intolerance to the drug.

Warnings

Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing patients to this rare event are not known. Patients should be instructed to report early signs and/or symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice. Chlorzoxazone should be discontinued immediately and a physician consulted if any of these signs or symptoms develop. …

Effets secondaires possibles

Chlorzoxazone containing products are usually well tolerated. It is possible in rare instances that chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, lightheadedness, malaise, or over-stimulation may be noted by an occasional patient. Rarely, allergic type skin rashes, petechiae, or ecchymoses may develop during treatment. Angioneurotic edema or anaphylactic reactions are extremely rare. There is no evidence that the drug will cause renal damage. Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone. This finding is of no known clinical significance. …

If you take too much

Symptoms Initially, gastrointestinal disturbances such as nausea, vomiting, or diarrhea together with drowsiness, dizziness, lightheadedness or headache may occur. Early in the course there may be malaise or sluggishness followed by marked loss of muscle tone, making voluntary movement impossible. The deep tendon reflexes may be decreased or absent. The sensorium remains intact, and there is no peripheral loss of sensation. Respiratory depression may occur with rapid, irregular respiration and intercostal and substernal retraction. …

En cas d'oubli

Prenez-le dès que vous y pensez, sauf s'il est presque l'heure de la dose suivante. Dans ce cas, sautez la dose oubliée. Ne prenez jamais deux doses à la fois pour compenser. Vérifiez votre notice, certains médicaments font exception.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2025-03-01.

Marques dans le monde

Products with Chlorzoxazone as the active ingredient. Names differ between countries.

Registered products

United States (FDA)

ChlorzoxazoneCHLORZOXAZONE 500 mg/1 · Tablet · Advanced Rx Pharmacy of Tennessee, LLC
NDC 80425-0315Label
ChlorzoxazoneCHLORZOXAZONE 35 kg/35kg · Powder · NURAY CHEMICALS PRIVATE LIMITED
NDC 58159-030Label
ChlorzoxazoneCHLORZOXAZONE 375 mg/1 · Tablet · Aurobindo Pharma Limited
NDC 59651-305Label
ChlorzoxazoneCHLORZOXAZONE 500 mg/1 · Tablet · Aurobindo Pharma Limited
NDC 59651-306Label
ChlorzoxazoneCHLORZOXAZONE 750 mg/1 · Tablet · Aurobindo Pharma Limited
NDC 59651-307Label

Nigeria (NAFDAC)

NAFDACLespen Tablets B4-6404NAFDACMyospaz Tablet B4-3633NAFDACNo-Ach Tablets B4-4263NAFDACkrusher Tablets A4-5859NAFDACParaflex Tablets A4-8018NAFDACSupergesic Tablets B4-6407NAFDACGebedol Forte Tablets A4-7313

Other countries: check your pack's registration number and we point you to your regulator.

Safety alerts and recalls

Chlorzoxazone Tablets USP 750 mg 100 Tablets Rx Only NDC 68462-725-01 Manufactured by: Glenmark Pharmaceuticals Inc., USA 4147 Goldmine Road Monroe, NC 28110 Manufactured for: GleU.S. FDA Class II
27 Aug 2021 · Glenmark Pharmaceuticals Inc., USA · TerminatedCGMP Deviations
Chlorzoxazone Tablets USP 375 mg 100 Tablets Rx Only NDC 68462-724-01 Manufactured by: Glenmark Pharmaceuticals Inc., USA 4147 Goldmine Road Monroe, NC 28110 Manufactured for: GleU.S. FDA Class II
27 Aug 2021 · Glenmark Pharmaceuticals Inc., USA · TerminatedCGMP Deviations

A recall usually affects certain batches only. Compare the lot number on your pack.

Check your pack of Chlorzoxazone

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Questions about Chlorzoxazone

What is Chlorzoxazone used for?

INDICATIONS Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man. (From the official U.S. FDA label.)

How do I take Chlorzoxazone?

Follow your prescription or the leaflet in your pack. The official label says: Usual Adult Dosage One tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.…

Do I need a prescription for Chlorzoxazone?

Usually yes. Chlorzoxazone is a prescription medicine in most countries. Rules differ by country.

What brands contain Chlorzoxazone?

Chlorzoxazone is sold under names such as Lorzone, Chlorzoxazone. Brand names differ between countries.

How can I check that my Chlorzoxazone is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.