What each one is for, how to take it, side effects and warnings, side by side from the official labels.
| Valsartan | Sacubitril | |
|---|---|---|
| What it is | A blood pressure medicine (ARB) | A blood pressure medicine (ARB) |
| Used for | Valsartan tablets are an angiotensin II receptor blocker (ARB) indicated for: Hypertension, to lower blood pressure in adults and children 1 year and older. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes… | is a combination of sacubitril, a neprilisin inhibitor, and valsartan, an angiotensin II receptor blocker, and is indicated: to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits… |
| Usual adult dose | Indication Starting Dose Dose Range * Hypertension Adult 80-160 mg once daily 80-320 mg once daily 1-16 years 1 mg/kg once daily Up to 40 mg daily 1-4 mg/kg once daily Up to 160 mg daily Heart Failure 40 mg twice daily 40-160 mg twice daily Post-Myocardial Inf… | Adults is 49 mg/51 mg orally twice daily. |
| Children | Use of the oral suspension is recommended: in pediatric patients aged 1 to 5 years in patients >5 years of age who cannot swallow tablets and in pediatric patients for whom the calculated dose (mg/kg) does not correspond to the available tablet strengths of va… | For pediatric patients, see the Full Prescribing Information for recommended dosage, titrations, preparation and administration instructions. |
| Prescription (U.S.) | Yes | Yes |
| Common side effects | Hypertension: Most common adverse reactions are headache, dizziness, viral infection, fatigue and abdominal pain ( 6.1 ) Heart Failure: Most common adverse reactions are dizziness, hypotension, diarrhea, arthralgia, back pain, fat… | Clinically significant adverse reactions that appear in other sections of the labeling include: Angioedema [see Warnings and Precautions (5.2)] Hypotension [see Warnings and Precautions (5.3)] Impaired Renal Function [see Warnings… |
| Serious warning | When pregnancy is detected, discontinue valsartan as soon as possible. ( 5.1 ) Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. ( 5.1 ) WARNI… | When pregnancy is detected, discontinue ENTRESTO as soon as possible (5.1) Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.1) WARNING: FET… |
| Pregnancy | Lactation: Breastfeeding is not recommended ( 8. 2) Pediatrics : Use of valsartan tablets is not recommended in children less than 1 year of age ( 6.1 , 8.4 , 13.2 ) 8.1 Pregnancy Risk Summary Valsart… | 8.1 Pregnancy Risk Summary ENTRESTO can cause fetal harm when administered to a pregnant woman. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnanc… |
From the official U.S. labels. Brands and strengths differ between countries.
The official labels mention them together: Avoid use of entresto with an arb, because entresto contains the angiotensin ii receptor blocker valsartan. Ask a pharmacist before combining them.
Check them togetherValsartan is a blood pressure medicine (ARB) and Sacubitril is a blood pressure medicine (ARB). Valsartan is used for: Valsartan tablets are an angiotensin II receptor blocker (ARB) indicated for: Hypertension, to lower blood pressure in adults and children 1 year and older. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes… Sacubitril is used for: is a combination of sacubitril, a neprilisin inhibitor, and valsartan, an angiotensin II receptor blocker, and is indicated: to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits…
The official labels mention them together: Avoid use of entresto with an arb, because entresto contains the angiotensin ii receptor blocker valsartan. Ask a pharmacist before combining them.
It depends on what you are treating, your health and other medicines. Your doctor or pharmacist can tell you which one suits you; this page shows what each official label says.