What each one is for, how to take it, side effects and warnings, side by side from the official labels.
| Atovaquone | Proguanil | |
|---|---|---|
| What it is | A malaria medicine | A malaria medicine |
| Used for | Atovaquone oral suspension is a quinone antimicrobial drug indicated for: Prevention of Pneumocystis jirovecii pneumonia (PCP) in adults and adolescents aged 13 years and older who cannot tolerate trimethoprim-sulfamethoxazole (TMP-SMX). ( 1.1 ) Treatment of m… | Atovaquone and proguanil hydrochloride tablets are an antimalarial indicated for: • prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. ( 1.1 ) • treatment of acute, uncomplicated P. falciparum malar… |
| Children | Evidence of safety and effectiveness in pediatric patients (aged 12 years and younger) has not been established. | Pediatric Patients: Dosage based on body weight (see Table 1). |
| Prescription (U.S.) | Yes | Yes |
| Common side effects | The following adverse reactions are discussed in other sections of the labeling: Hepatotoxicity [see Warnings and Precautions ( 5.2 )] . PCP Prevention: The most frequent adverse reactions (≥25% that required discontinuation) were… | The following clinically significant adverse reactions are discussed in another section of the labeling: • Vomiting and Diarrhea [see Warnings and Precautions ( 5.1 )]. • Hepatotoxicity [see Warnings and Precautions ( 5.3 )]. • Se… |
| Pregnancy | 8.1 Pregnancy Pregnancy Category C There are no adequate and well-controlled studies in pregnant women. Atovaquone should be used during pregnancy only if the potential benefit justifies the potential… | 8.1 Pregnancy Risk Summary Available data from published literature and postmarketing experience with use of atovaquone and proguanil hydrochloride in pregnant women are insufficient to identify a dru… |
From the official U.S. labels. Brands and strengths differ between countries.
The official labels mention them together: Administration with rifampin or rifabutin is known to reduce atovaquone concentrations. Ask a pharmacist before combining them.
Check them togetherAtovaquone is a malaria medicine and Proguanil is a malaria medicine. Atovaquone is used for: Atovaquone oral suspension is a quinone antimicrobial drug indicated for: Prevention of Pneumocystis jirovecii pneumonia (PCP) in adults and adolescents aged 13 years and older who cannot tolerate trimethoprim-sulfamethoxazole (TMP-SMX). ( 1.1 ) Treatment of m… Proguanil is used for: Atovaquone and proguanil hydrochloride tablets are an antimalarial indicated for: • prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. ( 1.1 ) • treatment of acute, uncomplicated P. falciparum malar…
The official labels mention them together: Administration with rifampin or rifabutin is known to reduce atovaquone concentrations. Ask a pharmacist before combining them.
It depends on what you are treating, your health and other medicines. Your doctor or pharmacist can tell you which one suits you; this page shows what each official label says.