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Controlled medicines

Some medicines can cause addiction or be deadly when misused. A pharmacist may only sell them with a doctor's prescription. Here is what they are, the rules, and where to get help.

The rules in Nigeria

  • Controlled medicines are sold only by a licensed pharmacist, only with a doctor's prescription. Patent medicine stores and roadside sellers may not sell them.
  • Codeine cough syrups have been banned (production and import) since May 2018.
  • Tramadol above 100 mg per tablet or capsule is not allowed. 50 mg and 100 mg are prescription-only.
  • NAFDAC also controls ketamine and tramadol nationally, even though they are not on the UN lists.
  • Heroin, cocaine, cannabis, LSD, methamphetamine ("mkpuru mmiri") and PCP are illegal. The NDLEA enforces this.

This page explains the rules for the public. It is not legal advice. Outside Nigeria, rules differ by country, but every medicine on this page is prescription-only or banned almost everywhere.

Check a medicine

Scan any pack: if it contains a controlled medicine, we tell you.

3 free checks left today Official sources: NAFDAC · WHO · U.S. FDA · Health Canada · NLM

Opioid painkillers and cough medicines

Fentanyl

Controlled medicine

Also known as Duragesic, Sublimaze, Actiq, Durogesic

Opioid painkiller. Very strong painkiller for severe pain and anaesthesia. About 100 times stronger than morphine.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once
  • Tiny amounts can be fatal; patches must be stored and thrown away carefully

UN 1961 Schedule I

How it is used safely →

Pethidine

Controlled medicine

Also known as Meperidine, Demerol

Opioid painkiller. Strong painkiller, used in labour and after surgery.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

How it is used safely →

Methadone

Controlled medicine

Also known as Dolophine, Physeptone, Methadose

Opioid. Treats opioid addiction and severe pain.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

How it is used safely →

Morphine

Controlled medicine

Also known as Mst Continus, Oramorph, Sevredol, Kapanol

Opioid painkiller. Strong painkiller for severe pain, cancer pain and end-of-life care.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

How it is used safely →

Oxycodone

Controlled medicine

Also known as Oxycontin, Oxynorm, Percocet, Roxicodone

Opioid painkiller. Strong painkiller for moderate to severe pain.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

How it is used safely →

Hydromorphone

Controlled medicine

Also known as Dilaudid, Palladone

Opioid painkiller. Strong painkiller for severe pain.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

How it is used safely →

Oxymorphone

Controlled medicine

Also known as Opana

Opioid painkiller. Strong painkiller for severe pain.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

How it is used safely →

Codeine

Controlled medicine

Also known as Codeine Phosphate, Co-codamol, Paracetamol And Codeine, Tylenol With Codeine

Opioid painkiller / cough medicine. Mild opioid for pain, cough and diarrhoea.

Codeine cough syrups have been banned in Nigeria since May 2018 (production and import). Codeine tablets remain prescription-only.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule II

How it is used safely →

Dihydrocodeine

Controlled medicine

Also known as Df118, Co-dydramol

Opioid painkiller. Mild-to-moderate opioid painkiller.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule II

How it is used safely →

Buprenorphine

Controlled medicine

Also known as Subutex, Suboxone, Temgesic, Butrans

Opioid. Treats opioid addiction and pain (tablets under the tongue, patches, injection).

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1971 Schedule III

How it is used safely →

Pentazocine

Controlled medicine

Also known as Fortwin, Talwin, Sosegon, Fortral

Opioid painkiller. Painkiller, mostly given by injection in Nigeria.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once
  • Injecting it causes skin ulcers and muscle damage

UN 1971 Schedule III

How it is used safely →

Tramadol

Controlled in Nigeria

Also known as Tramal, Ultram, Tramadol Hydrochloride, Zydol

Opioid painkiller. Painkiller for moderate to severe pain.

In Nigeria, tramadol above 100 mg per tablet or capsule is not allowed (NAFDAC, 2018). 50 mg and 100 mg are prescription-only.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once
  • Fits (seizures), even at normal doses in some people

Not on the UN lists; controlled nationally in Nigeria

How it is used safely →

Diphenoxylate

Controlled medicine

Also known as Lomotil, Co-phenotrope

Opioid anti-diarrhoea medicine. Stops diarrhoea. Usually combined with atropine to discourage misuse.

  • Dangerous for young children: can stop breathing
  • Misuse in high doses gives opioid effects

UN 1961 Schedule I (low-dose preparations with atropine are exempt)

How it is used safely →

Pholcodine

Controlled, and withdrawn in many countries

Also known as Pholcodine Linctus, Galenphol

Opioid cough medicine. Cough suppressant.

The European Medicines Agency recommended withdrawing all pholcodine medicines in December 2022. Tell your doctor or anaesthetist if you used it in the past year.

  • Linked to severe allergic reactions during later surgery under general anaesthesia
  • Drowsiness

UN 1961 Schedule II

How it is used safely →

Sedatives and sleeping pills (benzodiazepines and Z-drugs)

Diazepam

Controlled medicine

Also known as Valium, Stesolid, Diastat

Benzodiazepine (sedative). Anxiety, muscle spasm, alcohol withdrawal and fits.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Alprazolam

Controlled medicine

Also known as Xanax, Alprazolam Xr

Benzodiazepine (sedative). Anxiety and panic attacks.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Clonazepam

Controlled medicine

Also known as Rivotril, Klonopin

Benzodiazepine (sedative). Epilepsy and panic disorder.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Lorazepam

Controlled medicine

Also known as Ativan

Benzodiazepine (sedative). Anxiety, sleep before surgery and seizures.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Bromazepam

Controlled medicine

Also known as Lexotan, Lexotanil, Lectopam

Benzodiazepine (sedative). Anxiety.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Midazolam

Controlled medicine

Also known as Dormicum, Hypnovel, Buccolam, Versed

Benzodiazepine (sedative). Sedation before procedures and emergency treatment of fits.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Nitrazepam

Controlled medicine

Also known as Mogadon

Benzodiazepine (sleeping pill). Short-term treatment of sleeplessness.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Flunitrazepam

Controlled medicine

Also known as Rohypnol

Benzodiazepine (sleeping pill). Severe sleeplessness. Known as a "date-rape" drug.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule III

How it is used safely →

Temazepam

Controlled medicine

Also known as Restoril, Normison

Benzodiazepine (sleeping pill). Short-term treatment of sleeplessness.

  • Dependence after a few weeks of daily use; do not stop suddenly
  • Drowsiness, falls and road accidents
  • Dangerous with alcohol or opioid painkillers: breathing can stop

UN 1971 Schedule IV

How it is used safely →

Zolpidem

Controlled medicine

Also known as Stilnox, Ambien, Zolpidem Tartrate

Sleeping pill ("Z-drug"). Short-term treatment of sleeplessness.

  • Dependence
  • Sleep-walking, sleep-driving and memory gaps
  • Dangerous with alcohol and opioids

UN 1971 Schedule IV

How it is used safely →

Barbiturates and anaesthetics

Phenobarbital

Controlled medicine

Also known as Phenobarbitone, Luminal, Gardenal

Barbiturate. Epilepsy and fits, including in newborns.

  • Dependence and dangerous withdrawal fits
  • Small difference between a normal dose and a fatal one
  • Deadly with alcohol, opioids or benzodiazepines

UN 1971 Schedule IV

How it is used safely →

Pentobarbital

Controlled medicine

Also known as Nembutal

Barbiturate. Sedation and anaesthesia in hospitals.

  • Dependence and dangerous withdrawal fits
  • Small difference between a normal dose and a fatal one
  • Deadly with alcohol, opioids or benzodiazepines

UN 1971 Schedule III

How it is used safely →

Thiopental

Controlled medicine

Also known as Thiopentone, Pentothal, Sodium Thiopental

Barbiturate anaesthetic. Used only in hospitals to start general anaesthesia.

  • Dependence and dangerous withdrawal fits
  • Small difference between a normal dose and a fatal one
  • Deadly with alcohol, opioids or benzodiazepines

Not on the UN lists; hospital use only

How it is used safely →

Ketamine

Controlled in Nigeria

Also known as Ketalar, Esketamine

Anaesthetic. Anaesthesia and pain relief in hospitals.

  • Confusion, hallucinations
  • Bladder damage with repeated misuse
  • Accidents while intoxicated

Not on the UN lists; controlled nationally in Nigeria

How it is used safely →

Stimulants

Methylphenidate

Controlled medicine

Also known as Ritalin, Concerta, Medikinet, Equasym

Stimulant. ADHD and narcolepsy.

  • Addiction
  • Fast heartbeat, high blood pressure, stroke
  • Sleeplessness, anxiety, paranoia

UN 1971 Schedule II

How it is used safely →

Amphetamine

Controlled medicine

Also known as Adderall, Dexamfetamine, Dextroamphetamine, Lisdexamfetamine

Stimulant. ADHD and narcolepsy where approved.

  • Addiction
  • Fast heartbeat, high blood pressure, stroke
  • Sleeplessness, anxiety, paranoia

UN 1971 Schedule II

How it is used safely →

Methamphetamine

Controlled medicine

Also known as Crystal Meth, Mkpuru Mmiri, Desoxyn

Stimulant ("mkpuru mmiri", "ice"). Highly addictive stimulant; mostly made and sold illegally.

  • Addiction
  • Fast heartbeat, high blood pressure, stroke
  • Sleeplessness, anxiety, paranoia
  • Psychosis and violent behaviour

UN 1971 Schedule II

How it is used safely →

Antidepressants often misused

Amitriptyline

Prescription-only, often misused

Also known as Tryptanol, Elavil, Saroten, Triptyl

Tricyclic antidepressant. Depression, nerve pain and migraine prevention.

  • Overdose is very dangerous to the heart
  • Drowsiness and dizziness
  • Can interact with many medicines

Not on the UN lists

How it is used safely →

Clomipramine

Prescription-only, often misused

Also known as Anafranil

Tricyclic antidepressant. Depression, OCD and panic disorder.

  • Overdose is very dangerous to the heart
  • Drowsiness and dizziness
  • Can interact with many medicines

Not on the UN lists

How it is used safely →

Imipramine

Prescription-only, often misused

Also known as Tofranil

Tricyclic antidepressant. Depression and bed-wetting in children.

  • Overdose is very dangerous to the heart
  • Drowsiness and dizziness
  • Can interact with many medicines

Not on the UN lists

How it is used safely →

Illegal drugs (no legal use for the public)

Heroin

Illegal drug

Also known as Diamorphine

Opioid (illegal). No medical use for the public.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once
  • HIV and hepatitis from shared needles

UN 1961 Schedules I and IV

Cocaine

Illegal drug

Also known as Crack Cocaine

Stimulant (illegal). Rarely used by doctors as a local anaesthetic; street cocaine and crack are illegal.

  • Heart attack and stroke, even in young people
  • Strong addiction
  • Anxiety and paranoia

UN 1961 Schedule I

Cannabis

Illegal drug

Also known as Marijuana, Marihuana, Indian Hemp

Cannabis (illegal in Nigeria). Illegal to grow, sell or use in Nigeria.

  • Psychosis, especially in young people
  • Dependence
  • Memory and learning problems

UN 1961 Schedule I

Opium

Illegal drug

Opium (illegal). Raw opium has no approved use for the public.

  • Addiction and dependence, even when taken as prescribed
  • Slow or stopped breathing, especially with alcohol or sleeping pills
  • Overdose can kill: blue lips, pinpoint pupils, cannot be woken. Call for help at once

UN 1961 Schedule I

LSD

Illegal drug

Also known as Lysergic Acid Diethylamide, Lysergide

Hallucinogen (illegal). No medical use.

  • Frightening hallucinations ("bad trips")
  • Dangerous behaviour while intoxicated
  • Flashbacks

UN 1971 Schedule I

Phencyclidine

Illegal drug

Also known as Angel Dust

Hallucinogen (illegal). No medical use.

  • Violent or confused behaviour
  • Seizures, coma

UN 1971 Schedule II

Questions people ask

What is a controlled medicine?

A medicine that can cause addiction or be misused, so the law limits who can sell it. In Nigeria a licensed pharmacist may only sell it against a doctor's prescription.

Can a chemist or patent medicine store sell tramadol, codeine or diazepam without a prescription?

No. These are prescription-only controlled medicines. Codeine cough syrups have been banned in Nigeria since 2018, and tramadol above 100 mg per tablet is not allowed.

What should I do if a shop sold me a controlled medicine without a prescription?

Report it to NAFDAC free on 0800 1 623322, or use "Report a problem" after scanning the pack on PillVera.

Where can someone get help for drug use in Nigeria?

Call the NDLEA 24-hour drug help line free on 0800 1020 3040. In an emergency, call 112.

Are amitriptyline and other tricyclic antidepressants controlled?

They are not on the UN control lists, but they are prescription-only and are often misused. An overdose is very dangerous to the heart.