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Chloramphenicol

How to take it, side effects, brands around the world and safety alerts.

Checked against the official label · Updated

Prescription medicine Intravenous

Chloramphenicol: quick answers

Infancia
See DOSAGE AND ADMINISTRATION for dosing information in the pediatric population.
Prescription
Prescription medicine in the United States; rules differ by country.

From the official label (Oct 2024). Your prescription and pharmacist come first.

How to use Chloramphenicol

Lo que dice el prospecto oficial. Si te lo recetó un médico, sigue la receta. Si el prospecto de tu caja es distinto, manda el de tu caja.

Advertencia grave: Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia) are known to occur after the administration of chloramphenicol. In addition, there have been reports of aplastic anemia attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias have occurred after both short-term and prolonged therapy with this drug. …
Infancia
  • Precaution should be used in therapy of premature and full-term
  • Neonates and infants to avoid “gray syndrome” toxicity
  • Due to immature metabolic processes in the neonate and infant, excessive blood levels may result from administration of the recommended dose
  • The dosage should be adjusted accordingly or, preferable, the blood concentration should be determined at appropriate intervals (see ADVERSE REACTIONS , "Gray Syndrome" )
  • See DOSAGE AND ADMINISTRATION for dosing information in the pediatric population
Older adults

Clinical studies of chloramphenicol sodium succinate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. …

Talk to a doctor first if
  • Chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it
  • It must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat; or as a prophylactic agent to prevent bacterial infections
Medicines it may not mix with

Concurrent therapy with other drugs that may cause bone marrow depression should be avoided.

Warnings

PRECAUTIONS: General Repeated courses of chloramphenicol treatment should be avoided if at all possible. Treatment should not be continued longer than required to produce a cure with little or no risk or relapse of the disease. Excessive blood levels may result from administration of the recommended dose to patients with impaired liver or kidney function. The dosage should be adjusted accordingly, or preferably, the blood concentration should be determined at appropriate intervals. The use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. …

Posibles efectos secundarios

Blood Dyscrasias The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol. An irreversible type of marrow depression leading to aplastic anemia with a high rate of mortality is characterized by the appearance weeks or months after therapy of bone marrow aplasia or hypoplasia. Peripherally, pancytopenia is most often observed, but in a small number of cases only one or two of the three major cell types (erythrocytes, leukocytes, platelets) may be depressed. …

Pregnancy and breastfeeding

Pregnancy Pregnancy Category C – Animal reproduction studies have not been conducted with chloramphenicol. There are no adequate and well-controlled studies to establish safety of this drug in pregnancy. It is not known whether chloramphenicol can cause fetal harm when administered to a pregnant woman. Orally administered chloramphenicol has been shown to cross the placental barrier. …

Si olvidas una dosis

Tómala en cuanto te acuerdes, salvo que falte poco para la siguiente. En ese caso, sáltate la olvidada. Nunca tomes dos dosis a la vez para compensar. Revisa tu prospecto, porque algunos medicamentos son distintos.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2024-10-10.

How much Chloramphenicol costs

In other countries

Prices in other countries are not what you will pay where you live; they show how prices compare.

Marcas en todo el mundo

Products with Chloramphenicol as the active ingredient. Names differ between countries.

Registered products

United States (FDA)

ChloramphenicolCHLORAMPHENICOL 1 kg/kg · Powder · Jiangsu Lianhuan Pharmaceutical Co.,Ltd.
NDC 81918-002Label
ChloramphenicolCHLORAMPHENICOL 1 g/g · Powder · Nanjing White Whale Pharmaceutical Co., Ltd
NDC 66478-0155Label
Chloramphenicol PalmitateCHLORAMPHENICOL PALMITATE 1 kg/kg · Salve · Wang Pharmaceuticals & Chemicals
NDC 73361-003Label
ChloramphenicolCHLORAMPHENICOL 1 kg/kg · Powder · Quimica Sintetica S.A.
NDC 53069-0010Label
ChloramphenicolCHLORAMPHENICOL 1 kg/kg · Powder · Fagron Inc
NDC 51552-1419Label

Nigeria (NAFDAC)

NAFDACChloramphenicol 0.5% Eye Drops A11-0232NAFDACChloramphenicol Sterile Eye Drops 04-5588NAFDACChloramphenicol Succinate for Injection C4-1729NAFDACChlorakris A11-100386NAFDACDuban - 250 04-4815NAFDACDuban Injection B4-3671NAFDACClor 250 Capsules A4-0495NAFDACChloraf Suspension 04-0543NAFDACGramicol Eye Drops C4-1758NAFDACChlomacol Capsules 04-3728NAFDACDerm Chloramphenicol B4-6227NAFDACEliphenicol Capsules A4-1538

Other countries: check your pack's registration number and we point you to your regulator.

Check your pack of Chloramphenicol

Type the registration number on the pack, or scan it with your camera.

O haz fotos de la caja
Te quedan 3 verificaciones gratis hoy Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Chloramphenicol

Do I need a prescription for Chloramphenicol?

Usually yes. Chloramphenicol is a prescription medicine in most countries. Rules differ by country.

What brands contain Chloramphenicol?

Chloramphenicol is sold under names such as Viceton, Chloramphenicol Sodium Succinate. Brand names differ between countries.

What are the side effects of Chloramphenicol?

The official label lists: Blood Dyscrasias The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol. An irreversible type of marrow depression leading to aplastic anemia with a high rate of mortality is charac… Tell your doctor about any side effect that bothers you or does not go away.

Can children take Chloramphenicol?

Precaution should be used in therapy of premature and full-term neonates and infants to avoid “gray syndrome” toxicity. Due to immature metabolic processes in the neonate and infant, excessive blood levels may result from administration of the recommended dose. The dosage should be adjusted accordingly or, preferable, the blood concentration should be determined at appropriate… Always use the dose for the child's age or weight on the pack or prescription.

Can I take Chloramphenicol when pregnant or breastfeeding?

Pregnancy Pregnancy Category C – Animal reproduction studies have not been conducted with chloramphenicol. There are no adequate and well-controlled studies to establish safety of this drug in pregnancy. It is not known whether chloramphenicol can cause fetal harm when administered to a pregnant woman. Orally administered chloramphenicol has been shown to cross the placental ba… Ask your doctor or midwife first.

What medicines interact with Chloramphenicol?

Concurrent therapy with other drugs that may cause bone marrow depression should be avoided. Use the free interaction checker before combining medicines.

How can I check that my Chloramphenicol is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.