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Memantine

Memantine is a brand of Memantine.

Memantine hydrochloride tablets are indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. Memantine hydrochloride tablet.

Checked against the official label · Updated

Prescription medicine Oral Safety alerts on record

Memantine: quick answers

Used for
Memantine hydrochloride tablets are indicated for the treatment of moderate to severe dementia of the Alzheimer’s type.
Infancia
Safety and effectiveness in pediatric patients have not been established.
With food?
Memantine hydrochloride tablets can be taken with or without food.
Prescription
Prescription medicine in the United States; rules differ by country.

From the official label (Aug 2023). Your prescription and pharmacist come first.

How to use Memantine

Lo que dice el prospecto oficial. Si te lo recetó un médico, sigue la receta. Si el prospecto de tu caja es distinto, manda el de tu caja.

Para quién es

Memantine hydrochloride tablets are indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. Memantine hydrochloride tablets are an N-methyl-D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. (1)

Cómo tomarlo y con qué frecuencia
  • The recommended starting dose of memantine hydrochloride tablets is 5 mg once daily
  • The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice daily)
  • The minimum recommended interval between dose increases is one week
  • The dosage shown to be effective in controlled clinical trials is 20 mg/day
  • Memantine hydrochloride tablets can be taken with or without food
  • If a patient misses a single dose of memantine hydrochloride tablets, that patient should not double up on the next dose
  • The next dose should be taken as scheduled
  • If a patient fails to take memantine hydrochloride tablets for several days, dosing may need to be resumed at lower doses and retitrated as described above
  • Specific Populations Renal Impairment A target dose of 5 mg twice daily is recommended in patients with severe renal impairment (creatinine clearance of 5 to 29 mL/min based on the Cockcroft-Gault equation)
  • Hepatic Impairment Memantine hydrochloride tablets should be administered with caution to patients with severe hepatic impairment [see Clinical Pharmacology ]
  • May be taken with or without food
  • Initial dose is 5 mg once daily
  • Increase dose in 5 mg increments to a maintenance dose of 10 mg twice daily
  • A minimum of 1 week of treatment with the previous dose should be observed before increasing the dose
Fortalezas en las que viene

Memantine Hydrochloride Tablet USP, 5 mg: orange colored, oblong, biconvex, film-coated tablets debossed “IP 173” on one side and plain on the other side. Memantine Hydrochloride Tablet USP, 10 mg: gray colored, oblong, biconvex, film-coated tablets debossed “IP 174” on one side and plain on the other side. Tablets: 5 mg and 10 mg (3)

Infancia
  • Safety and effectiveness
  • In pediatric patients have not been established
  • Memantine failed to demonstrate efficacy in two 12-week controlled clinical studies of 578
  • Pediatric patients aged 6 to 12 years with autism spectrum disorders (ASD), including autism, Asperger’s disorder and Pervasive Development Disorder - Not Otherwise Specified (PDD-NOS)
  • Memantine has not been studied
  • In pediatric patients under 6 years of age or over 12 years of age
  • Memantine treatment was initiated at 3 mg/day and the dose was escalated to the target dose (weight-based) by week 6. …
Older adults

The majority of people with Alzheimer’s disease are 65 years and older. In the clinical studies of memantine hydrochloride the mean age of patients was approximately 76; over 90% of patients were 65 years and older, 60% were 75 years and older, and 12% were at or above 85 years of age. The efficacy and safety data presented in the clinical trial sections were obtained from these patients. …

While you are taking it
  • See FDA-approved patient labeling (Patient Information)
  • To assure safe and effective use of memantine hydrochloride, the following information and instructions provided in the patient information section should be discussed with patients and caregivers
  • Patients/caregivers should be instructed to follow the dose titration schedule provided by their physician or healthcare professional for memantine hydrochloride
  • They should be warned not to use any tablets of memantine hydrochloride that are damaged or show signs of tampering
  • If a patient misses a single dose of memantine hydrochloride, that patient should not double up on the next dose
  • The next dose should be taken as scheduled. …
Talk to a doctor first if
  • Memantine hydrochloride tablets are contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation
  • Memantine hydrochloride tablets are contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation
Medicines it may not mix with

7.1 Drugs that Make the Urine Alkaline The clearance of memantine was reduced by about 80% under alkaline urine conditions at pH 8. Therefore, alterations of urine pH towards the alkaline condition may lead to an accumulation of the drug with a possible increase in adverse effects. Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). Hence, memantine should be used with caution under these conditions. …

Warnings

Conditions that raise urine pH may decrease the urinary elimination of memantine, resulting in increased plasma levels of memantine. (5.1, 7.1) 5.1 Genitourinary Conditions Conditions that raise urine pH may decrease the urinary elimination of memantine resulting in increased plasma levels of memantine [see Drug Interactions (7.1) ] .

Posibles efectos secundarios

Most common adverse reactions (≥ 5 % and greater than placebo) are dizziness, headache, confusion and constipation. (6.1) To report SUSPECTED ADVERSE REACTIONS, contact Amneal Pharmaceuticals at 1-877-835-5472 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials involving a total of 1862 dementia (Alzheimer’s disease, vascular dementia) patients (940 patients treated with memantine hydrochloride and 922 patients treated with placebo) for a treatment period up to 28 weeks. …

Pregnancy and breastfeeding

8.1 Pregnancy Risk Summary There are no adequate data on the developmental risk associated with the use of memantine hydrochloride in pregnant women. Adverse developmental effects (decreased body weight, and skeletal ossification) were observed in the offspring of rats administered memantine during pregnancy at doses associated with minimal maternal toxicity. …

If you take too much

Signs and symptoms most often accompanying memantine overdosage in clinical trials and from worldwide marketing experience, alone or in combination with other drugs and/or alcohol, include agitation, asthenia, bradycardia, confusion, coma, dizziness, ECG changes, increased blood pressure, lethargy, loss of consciousness, psychosis, restlessness, slowed movement, somnolence, stupor, unsteady gait, visual hallucinations, vertigo, vomiting, and weakness. …

Si olvidas una dosis

Tómala en cuanto te acuerdes, salvo que falte poco para la siguiente. En ese caso, sáltate la olvidada. Nunca tomes dos dosis a la vez para compensar. Revisa tu prospecto, porque algunos medicamentos son distintos.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2023-08-17.

How much Memantine costs

In other countries

Prices in other countries are not what you will pay where you live; they show how prices compare.

Same medicine, other brands

Products with Memantine as the active ingredient. Names differ between countries.

Registered products

United States (FDA)

Memantine HydrochlorideMEMANTINE HYDROCHLORIDE 7 mg/1 · Capsule, Extended Release · Lupin Pharmaceuticals, Inc.
NDC 68180-246Label
Memantine HydrochlorideMEMANTINE HYDROCHLORIDE 14 mg/1 · Capsule, Extended Release · Lupin Pharmaceuticals, Inc.
NDC 68180-247Label
Memantine HclMEMANTINE HYDROCHLORIDE 100 kg/100kg · Powder · SICOR Societa' Italiana Corticosteroidi s.r.l.
NDC 48292-0042Label
Memantine HydrochlorideMEMANTINE HYDROCHLORIDE 5 mg/1 · Tablet · A-S Medication Solutions
NDC 50090-6291Label
Memantine HydrochlorideMEMANTINE HYDROCHLORIDE 21 mg/1 · Capsule, Extended Release · Lupin Pharmaceuticals, Inc.
NDC 68180-248Label

Other countries: check your pack's registration number and we point you to your regulator.

Safety alerts and recalls

Memantine Hydrochloride Extended-Release, Capsules, 7 mg, 100 Capsules (10 x 10 blister packs), Rx only, Packaged and Distributed by: Major Pharmaceuticals, Indianapolis, IN 46268,U.S. FDA Class II
24 Mar 2026 · The Harvard Drug Group LLC · OngoingFailed Dissolution Specifications
Namzaric (memantine HCl extended release and donepezil HCl) capsules 14 mg/10 mg per capsule 30 capsules Rx Only NDC 0456-1214-30 Distributed by Forest Pharmaceuticals, Inc. SubsidU.S. FDA Class II
15 Mar 2021 · Cardinal Health Inc. · TerminatedCGMP Deviations: Intermittent exposure to temperature excursion during storage.
Memantine Hydrochloride Extended-Release Capsules, 28 mg, 100 capsules per unit dose cartons, Rx only, Manufactured by: Lupin Limited, Pithampur (M.P.)-454 775, India; Distributed U.S. FDA Class III
24 Apr 2020 · The Harvard Drug Group · TerminatedFailed dissolution specifications: Low stage 3 results obtained for dissolution during routine stability testing.
Memantine Hydrochloride Extended-release Capsules, 28mg, packaged in 100-count Unit Dose Cartons , Rx only, Manufactured for: Lupin Pharmaceuticals, Inc., Baltimore, Maryland 2120U.S. FDA Class III
13 Dec 2019 · The Harvard Drug Group · TerminatedFailed Dissolution Specifications: High out of specification result observed at stability studies.

A recall usually affects certain batches only. Compare the lot number on your pack.

Check your pack of Memantine

Type the registration number on the pack, or scan it with your camera.

O haz fotos de la caja
Te quedan 3 verificaciones gratis hoy Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Memantine

What is in Memantine?

Memantine contains Memantine. Other brands with the same active ingredient work the same way; the dose and strength on your pack are what matter.

What is Memantine used for?

Memantine hydrochloride tablets are indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. Memantine hydrochloride tablets are an N-methyl-D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. (1) (From the official U.S. FDA label.)

How do I take Memantine?

Follow your prescription or the leaflet in your pack. The official label says: The recommended starting dose of memantine hydrochloride tablets is 5 mg once daily. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice daily). The minimum recommended interval between dose increases is one week. The dosage shown to be effective in controlled clinical trials i…

Should I take Memantine with food?

Memantine hydrochloride tablets can be taken with or without food.

Do I need a prescription for Memantine?

Usually yes. Memantine is a prescription medicine in most countries. Rules differ by country.

What brands contain Memantine?

Memantine is sold under names such as Namzaric, Namenda, Memantine Hydrochloride. Brand names differ between countries.

What are the side effects of Memantine?

The official label lists: Most common adverse reactions (≥ 5 % and greater than placebo) are dizziness, headache, confusion and constipation. (6.1) To report SUSPECTED ADVERSE REACTIONS, contact Amneal Pharmaceuticals at 1-877-835-5472 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials inv… Tell your doctor about any side effect that bothers you or does not go away.

Can children take Memantine?

Safety and effectiveness in pediatric patients have not been established. Memantine failed to demonstrate efficacy in two 12-week controlled clinical studies of 578 pediatric patients aged 6 to 12 years with autism spectrum disorders (ASD), including autism, Asperger’s disorder and Pervasive Development Disorder - Not Otherwise Specified (PDD-NOS). Memantine has not been studie… Always use the dose for the child's age or weight on the pack or prescription.

Can I take Memantine when pregnant or breastfeeding?

8.1 Pregnancy Risk Summary There are no adequate data on the developmental risk associated with the use of memantine hydrochloride in pregnant women. Adverse developmental effects (decreased body weight, and skeletal ossification) were observed in the offspring of rats administered memantine during pregnancy at doses associated with minimal maternal toxicity. … Ask your doctor or midwife first.

What medicines interact with Memantine?

7.1 Drugs that Make the Urine Alkaline The clearance of memantine was reduced by about 80% under alkaline urine conditions at pH 8. Therefore, alterations of urine pH towards the alkaline condition may lead to an accumulation of the drug with a possible increase in adverse effects. Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and c… Use the free interaction checker before combining medicines.

What happens if I take too much Memantine?

Signs and symptoms most often accompanying memantine overdosage in clinical trials and from worldwide marketing experience, alone or in combination with other drugs and/or alcohol, include agitation, asthenia, bradycardia, confusion, coma, dizziness, ECG changes, increased blood pressure, lethargy… Get medical help right away.

How can I check that my Memantine is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.