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Prochlorperazine

Prochlorperazine is a brand of Prochlorperazine.

For control of severe nausea and vomiting. For the treatment of schizophrenia. Prochlorperazine is effective for the short-term treatment of generaliz.

Checked against the official label · Updated

Prescription medicine Oral Safety alerts on record

How to use Prochlorperazine

Ce que dit la notice officielle. Si un médecin vous l'a prescrit, suivez l'ordonnance. La notice de votre boîte prime si elle est différente.

Mise en garde grave : Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. …
Pour qui

For control of severe nausea and vomiting. For the treatment of schizophrenia. Prochlorperazine is effective for the short-term treatment of generalized non-psychotic anxiety. However, prochlorperazine is not the first drug to be used in therapy for most patients with non-psychotic anxiety, because certain risks associated with its use are not shared by common alternative treatments (e.g., benzodiazepines). …

Comment le prendre et à quelle fréquence
  • ADULTS (For children’s dosage and administration, see below.) Dosage should be increased more gradually in debilitated or emaciated patients
  • Elderly Patients: In general, dosages in the lower range are sufficient for most
  • Elderly patients
  • Since they appear to be more susceptible to hypotension and neuromuscular reac­tions, such patients should be observed closely
  • Dosage should be tailored to the individual, response carefully moni­tored and dosage adjusted accordingly
  • Dosage should be increased more gradually in elderly patients. 1.To Control Severe Nausea and Vomiting: Adjust dosage to the response of the individual
  • Begin with the lowest recommended dosage
  • Oral Dosage-Tablets: Usually one 5mg or 10mg tablet 3 or 4 times daily
  • Daily dosages above 40 mgs should be used only in resistant cases. 2.In Adult Psychiatric Disorders: Adjust dosage to the response of the individual and according to the severity of the condition
  • Begin with the lowest recom­mended dose
  • Although response ordinarily is seen within a day or 2, longer treatment is usually required before maximal improvement is seen
  • Oral Dosage: Non-Psychotic Anxiety--Usual dosage is 5 mg 3 or4 times daily
  • Do not administer in doses of more than 20mg per day or for longer than 12 weeks
  • Psychotic Disorders including Schizophrenia -- In relatively mild conditions , as seen in private psychiatric practice or in out patient clinics, dosage is 5 or 10 mg 3 or 4 times daily
Talk to a doctor first if
  • Do not use in patients with known hypersensitivity to phenothiazines
  • Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.)
  • Do not use
  • In pediatric surgery
  • Do not use
  • In pediatric patients under 2 years of age or under 20 lbs
  • Do not use in children for conditions for which dosage has not been established
Warnings

Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Prochlorperazine maleate is not approved for the treatment of patients with dementia-related psychosis (see BOXED WARNING ). The extrapyramidal symptoms which can occur secondary to prochlorperazine may be confused with the central nervous system signs of an undiagnosed primary disease responsible for the vomiting, e.g., Reye’s syndrome or other encephalopathy. …

Effets secondaires possibles

Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see WARNINGS ). Cholestatic jaundice has occurred. If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment. There have been a few observations of fatty changes in the livers of patients who have died while receiving the drug. No causal relationship has been established. Leukopenia and agranulocytosis have occurred. Warn patients to report the sudden appearance of sore throat or other signs of infection. …

If you take too much

(See also ADVERSE REACTIONS . ) SYMPTOMS --Primarily involvement of the extrapyramidal mechanism producing some of the dystonic reactions described above. Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus. TREATMENT--It is important to determine other medications taken by the patient since multiple-dose therapy is common in overdosage situations. …

How to store it

STORAGE Store at 20 to 25°C (68 to 77°F) [See USP Controlled Room Temperature]. Protect from light. Dispense in a tight, light-resistant container. * norepinephrine bitartrate, Abbott Laboratories. …

En cas d'oubli

Prenez-le dès que vous y pensez, sauf s'il est presque l'heure de la dose suivante. Dans ce cas, sautez la dose oubliée. Ne prenez jamais deux doses à la fois pour compenser. Vérifiez votre notice, certains médicaments font exception.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2022-10-09.

Same medicine, other brands

Products with Prochlorperazine as the active ingredient. Names differ between countries.

Registered products

United States (FDA)

Prochlorperazine MaleatePROCHLORPERAZINE MALEATE 10 mg/1 · Tablet, Film Coated · Leading Pharma, LLC
NDC 69315-266Label
Prochlorperazine MaleatePROCHLORPERAZINE MALEATE 5 mg/1 · Tablet, Film Coated · ANI Pharmaceuticals, Inc.
NDC 70954-688Label
Prochlorperazine MaleatePROCHLORPERAZINE MALEATE 10 mg/1 · Tablet, Film Coated · ANI Pharmaceuticals, Inc.
NDC 70954-689Label
Prochlorperazine MaleatePROCHLORPERAZINE MALEATE 5 mg/1 · Tablet · Ajanta Pharma USA Inc.
NDC 27241-286Label
Prochlorperazine MaleatePROCHLORPERAZINE MALEATE 10 mg/1 · Tablet · Ajanta Pharma USA Inc.
NDC 27241-287Label

Other countries: check your pack's registration number and we point you to your regulator.

Safety alerts and recalls

Prochlorperazine Maleate Tablets, 10mg, 100-count bottles, Rx Only, Manufactured by: Glenmark Pharmaceuticals Limited, Pithampur, Madhya Pradesh 454775, India, Manufactured for: GlU.S. FDA Class II
13 Mar 2025 · Glenmark Pharmaceuticals Inc., USA · OngoingCGMP Deviations
Prochlorperazine Maleate Tablets, USP 5mg, 100 tablets, RX Only, Jubilant Cadista Pharmaceuticals, Inc., Salisbury, Maryland 21801, NDC 59746-113-06U.S. FDA Class III
27 Dec 2022 · Jubilant Cadista Pharmaceuticals, Inc. · TerminatedSubpotent Drug: Out of specification for assay at the 18-month stability timepoint.
PROCHLORPERAZINE EDISYLATE INJECTION, USP 10 mg/2mL (5mg/mL), 2mL Vial, Rx Only, Mfg by: Emcure Pharmaceuticals Ltd., Hinjawadi, Pune, India. Mfg for: Heritage Pharmaceuticals Inc.U.S. FDA Class I
21 May 2019 · Heritage Pharmaceuticals, Inc. · TerminatedNon-Sterility:Microbial growth detected in sub lot of Amikacin Sulfate Injection, USP 1gm/4 mL (250mg/mL) and Prochlorperazine Edisylate Injection, USP 10mg/2mL (5mg/mL) .

A recall usually affects certain batches only. Compare the lot number on your pack.

Check your pack of Prochlorperazine

Type the registration number on the pack, or scan it with your camera.

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Encore 3 vérifications gratuites aujourd'hui Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Prochlorperazine

What is in Prochlorperazine?

Prochlorperazine contains Prochlorperazine. Other brands with the same active ingredient work the same way; the dose and strength on your pack are what matter.

What is Prochlorperazine used for?

For control of severe nausea and vomiting. For the treatment of schizophrenia. Prochlorperazine is effective for the short-term treatment of generalized non-psychotic anxiety. However, prochlorperazine is not the first drug to be used in therapy for most patients with non-psychotic anxiety, because certain risks associated with its use are not shared by common alternative treatments (e.g., benzodiazepines). … (From the official U.S. FDA label.)

How do I take Prochlorperazine?

Follow your prescription or the leaflet in your pack. The official label says: - ADULTS (For children’s dosage and administration, see below.) Dosage should be increased more gradually in debilitated or emaciated patients. Elderly Patients: In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reac­tions, such patients should be observed closely. Dosage sh…

Do I need a prescription for Prochlorperazine?

Usually yes. Prochlorperazine is a prescription medicine in most countries. Rules differ by country.

What brands contain Prochlorperazine?

Prochlorperazine is sold under names such as Compazine, Compro. Brand names differ between countries.

What are the side effects of Prochlorperazine?

The official label lists: Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see WARNINGS ). Cholestatic jaundice has occurred. If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment.… Tell your doctor about any side effect that bothers you or does not go away.

What happens if I take too much Prochlorperazine?

(See also ADVERSE REACTIONS . ) SYMPTOMS --Primarily involvement of the extrapyramidal mechanism producing some of the dystonic reactions described above. Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manif… Get medical help right away.

How should I store Prochlorperazine?

Store at 20 to 25°C (68 to 77°F) [See USP Controlled Room Temperature]. Protect from light. Dispense in a tight, light-resistant container. * norepinephrine bitartrate, Abbott Laboratories. …

How can I check that my Prochlorperazine is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.