Ciprofolxacin

Click here to enter Indications Ciprofloxacin is a fluoroquinolone antibacterial indicated in adults (18 years of age and older) with the following infections caused by designated, susceptible bacteria and in pediatric patients where indicated: • Skin and Skin Structure Infections ( Error! Hyperlink reference not valid. ) • Bone and Joint Infections ( Error! Hyperlink reference not valid. ) • Complicated Intra-Abdominal Infections ( Error! Hyperlink reference not valid. ) • Infectious Diarrhea ( Error! Hyperlink reference not valid. ) • Typhoid Fever (Enteric Fever) ( Error! Hyperlink reference not valid. …

• Ciprofloxacin tablets should be administered orally as described in the appropriate Dosage Guidelines tables
• Adult Dosage Guidelines Infection Dose Frequency Duration Skin and Skin Structure 500 -750 mg every 12 hours 7 to 14 days Bone and Joint 500-750 mg every 12 hours 4 to 8 weeks Complicated Intra-Abdominal 500 mg every 12 hours 7 to 14 days Infectious Diarrhea 500 mg every 12 hours 5 to 7 days Typhoid Fever 500 mg every 12 hours 10 days Uncomplicated Gonorrhea 250 mg single dose single dose Inhalational anthrax (post-exposure) 500 mg every 12 hours 60 days Plague 500–750 mg every 12 hours 14 days Chronic Bacterial Prostatitis 500 mg every 12 hours 28 days Lower Respiratory Tract 500 -750 mg every 12 hours 7 to 14 days Urinary Tract 250-500 mg every 12 hours 7 to 14 days Acute Uncomplicated Cystitis 250 mg every 12 hours 3 days Acute Sinusitis 500 mg every 12 hours 10 days • Adults with creatinine clearance 30–50 mL/min 250–500 mg q 12 h ( Error! Hyperlink reference not valid. ) • Adults with creatinine clearance 5–29 mL/min 250–500 mg q 18 h ( Error! Hyperlink reference not valid. ) • Patients on hemodialysis or peritoneal dialysis 250–500 mg q 24 h (after dialysis) ( Error! Hyperlink reference not valid. …

• Ciprofloxacin Tablets, USP 500 mg, white, oval shaped tablets, plain on one side, and “Y102” with no breakline on the other side. • Tablets: 500 mg (3)

• Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse reactions compared to controls
• Quinolones, including ciprofloxacin, cause arthropathy (arthralgia, arthritis), in juvenile animals [seeWarnings and Precautions ( Error! Hyperlink reference not valid. ) and Nonclinical Toxicology ( Error! Hyperlink reference not valid. )]. …

Geriatric patients are at increased risk for developing severe tendon disorders including tendon rupture when being treated with a fluoroquinolone such as ciprofloxacin. This risk is further increased in patients receiving concomitant corticosteroid therapy. …

• Advise the patient to read the FDA -approved patient labeling. (Medication Guide) Serious Adverse Reactions Advise patients to stop taking ciprofloxacin tablets if they experience an adverse reaction and to call their healthcare provider for advice on completing the full course of treatment with another antibacterial drug
• Inform patients of the following serious adverse reactions that have been associated with ciprofloxacin or other fluoroquinolone use: • Disabling and potentially irreversible serious adverse reactions that may occur together: Inform patients that disabling and potentially irreversible serious adverse reactions, including tendinitis and tendon rupture, peripheral neuropathi …

• Click here to enter Contraindications • Known hypersensitivity to ciprofloxacin or other quinolones ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid
• Error! Hyperlink reference not valid. ) • Concomitant administration with tizanidine Error! Hyperlink reference not valid. …

Ciprofloxacin is an inhibitor of human cytochrome P450 1A2 (CYP1A2) mediated metabolism. Co-administration of ciprofloxacin with other drugs primarily metabolized by CYP1A2 results in increased plasma concentrations of these drugs and could lead to clinically significant adverse events of the co-administered drug. Table 8: Drugs That are Affected by and Affecting Ciprofloxacin Drugs That are Affected by Ciprofloxacin Drug(s) Recommendation Comments Tizanidine Contraindicated Concomitant administration of tizanidine and ciprofloxacin is contraindicated due to the potentiation of hypotensive and sedative effects of tizanidine [see Contraindications ( Error! Hyperlink reference not valid. )]. …

Click here to enter Warnings and Precautions • Hypersensitivity and other serious reactions: Serious and sometimes fatal reactions (for example, anaphylactic reactions) may occur after the first or subsequent doses of ciprofloxacin. Discontinue ciprofloxacin at the first sign of skin rash, jaundice or any sign of hypersensitivity. ( Error! Hyperlink reference not valid. , 5.6 , Error! Hyperlink reference not valid. ) • Hepatotoxicity: Discontinue immediately if signs and symptoms of hepatitis occur. ( Error! Hyperlink reference not valid. ) • Clostridioides difficile-associated diarrhea: Evaluate if colitis occurs. ( Error! Hyperlink reference not valid. …

The following serious and otherwise important adverse drug reactions are discussed in greater detail in other sections of labeling: • Disabling and Potentially Irreversible Serious Adverse Reactions [see Warnings and Precautions ( Error! Hyperlink reference not valid. )] • Tendinitis and Tendon Rupture [see Warnings and Precautions ( Error! Hyperlink reference not valid. )] • Peripheral Neuropathy [see Warnings and Precautions ( Error! Hyperlink reference not valid. )] • Central Nervous System Effects [see Warnings and Precautions ( Error! Hyperlink reference not valid. )] Exacerbation of Myasthenia Gravis [see Warnings and Precautions ( Error! Hyperlink reference not valid. …

8.1 Pregnancy Risk Summary Prolonged experience with ciprofloxacin in pregnant women over several decades, based on available published information from case reports, case control studies and observational studies on ciprofloxacin administered during pregnancy, have not identified any drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes (see Data). …

In the event of acute overdosage, reversible renal toxicity has been reported in some cases. Empty the stomach by inducing vomiting or by gastric lavage. Observe the patient carefully and give supportive treatment, including monitoring of renal function, urinary pH and acidify, if required, to prevent crystalluria and administration of magnesium, aluminum, or calcium containing antacids which can reduce the absorption of ciprofloxacin. Adequate hydration must be maintained. Only a small amount of ciprofloxacin (less than 10%) is removed from the body after hemodialysis or peritoneal dialysis.

Take it when you remember, unless it is nearly time for the next dose. Then skip the missed one. Never take two doses at once to make up for it. Check your leaflet, as some medicines are different.