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Colestipol

Since no drug is innocuous, strict attention should be paid to the indications and contraindications, particularly when selecting drugs for chronic lo.

Checked against the official label · Updated

Prescription medicine Oral

Colestipol: quick answers

Used for
Since no drug is innocuous, strict attention should be paid to the indications and contraindications, particularly when selecting drugs for chronic long-term use.
Usual adult dose
For adults, colestipol hydrochloride tablets are recommended in doses of 2 to 16 grams/day given once or in divided doses.
Children
With food?
If you have had swallowing problems or choking with food, liquids or other tablets or capsules in the past, you should discuss this with your doctor before taking colestipol hydrochloride tablets.
Prescription
Prescription medicine in the United States; rules differ by country.

From the official label (May 2025). Your prescription and pharmacist come first.

How to use Colestipol

What the official label says. If a doctor prescribed it, follow the prescription. Your pack's leaflet comes first if it is different.

Who it is for

Since no drug is innocuous, strict attention should be paid to the indications and contraindications, particularly when selecting drugs for chronic long-term use. Colestipol hydrochloride tablets are indicated as adjunctive therapy to diet for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet. Generally, colestipol hydrochloride tablets have no clinically significant effect on serum triglycerides, but with their use, triglyceride levels may be raised in some patients. …

How to take it and how often
  • For adults, colestipol hydrochloride tablets are recommended in doses of 2 to 16 grams/day given once or in divided doses
  • The starting dose should be 2 grams once or twice daily
  • Dosage increases of 2 grams, once or twice daily should occur at 1-or 2-month intervals
  • Appropriate use of lipid profiles as per NCEP guidelines including LDL-C and triglycerides, is advised so that optimal but not excessive doses are used to obtain the desired therapeutic effect on LDL-C level
  • If the desired therapeutic effect is not obtained at a dose of 2 to 16 grams/day with good compliance and acceptable side effects, combined therapy or alternate treatment should be considered
  • Colestipol hydrochloride tablets must be taken one at a time and be promptly swallowed whole, using plenty of water or other appropriate liquid
  • Do not cut, crush, or chew the tablets
  • Patients should take other drugs at least one hour before or four hours after colestipol hydrochloride tablets to minimize possible interference with their absorption. (See Drug Interactions.) Before Administration of Colestipol Hydrochloride Tablets Define the type of hyperlipoproteinemia, as described in NCEP guidelines
  • Institute a trial of diet and weight reduction
  • Establish baseline serum total and LDL-C and triglyceride levels
  • During Administration of Colestipol Hydrochloride Tablets The patient should be carefully monitored clinically, including serum cholesterol and triglyceride levels. …
Children

Safety and effectiveness in the pediatric population have not been established.

While you are taking it
  • Colestipol hydrochloride tablets may be larger than pills you have taken before
  • If you have had swallowing problems or choking with food, liquids or other tablets or capsules in the past, you should discuss this with your doctor before taking colestipol hydrochloride tablets
  • It is important that you take colestipol hydrochloride tablets correctly: Always take one tablet at a time and swallow promptly
  • Swallow each tablet whole
  • Do not cut, crush, or chew the tablets
  • Colestipol hydrochloride tablets must be taken with water or another liquid that you prefer
  • Swallowing the tablets will be easier if you drink plenty of liquid as you
  • Swallow each tablet. …
Talk to a doctor first if

Colestipol hydrochloride tablets are contraindicated in those individuals who have shown hypersensitivity to any of their components.

Medicines it may not mix with

Since colestipol hydrochloride is an anion exchange resin, it may have a strong affinity for anions other than the bile acids. In vitro studies have indicated that colestipol hydrochloride binds a number of drugs. Therefore, colestipol hydrochloride tablets may delay or reduce the absorption of concomitant oral medication. The interval between the administration of colestipol hydrochloride tablets and any other medication should be as long as possible. Patients should take other drugs at least one hour before or four hours after colestipol hydrochloride tablets to avoid impeding their absorption. …

Warnings

PRECAUTIONS Prior to initiating therapy with colestipol hydrochloride tablets, secondary causes of hypercholesterolemia (e.g., poorly controlled diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemias, obstructive liver disease, other drug therapy, alcoholism), should be excluded, and a lipid profile performed to assess total cholesterol, HDL-C, and triglycerides (TG). For individuals with TG less than 400 mg/dL (400 mg/dL, this equation is less accurate and LDL-C concentrations should be determined by ultracentrifugation. In hypertriglyceridemic patients, LDL-C may be low or normal despite elevated Total-C. In such cases colestipol hydrochloride tablets may not be indicated. …

Possible side effects

Gastrointestinal The most common adverse reactions are confined to the gastrointestinal tract. To achieve minimal GI disturbance with an optimal LDL-C lowering effect, a gradual increase of dosage starting with 2 grams, once or twice daily is recommended. Constipation is the major single complaint and at times is severe. Most instances of constipation are mild, transient, and controlled with standard treatment. Increased fluid intake and inclusion of additional dietary fiber should be the first step; a stool softener may be added if needed. Some patients require decreased dosage or discontinuation of therapy. Hemorrhoids may be aggravated. …

Pregnancy and breastfeeding

In Pregnancy Since colestipol hydrochloride is essentially not absorbed systemically (less than 0.17% of the dose), it is not expected to cause fetal harm when administered during pregnancy in recommended dosages. There are no adequate and well-controlled studies in pregnant women, and the known interference with absorption of fat-soluble vitamins may be detrimental even in the presence of supplementation. …

If you take too much

Overdosage of colestipol hydrochloride tablets has not been reported. Should overdosage occur, however, the chief potential harm would be obstruction of the gastrointestinal tract. The location of such potential obstruction, the degree of obstruction and the presence or absence of normal gut motility would determine treatment.

If you miss a dose

Take it when you remember, unless it is nearly time for the next dose. Then skip the missed one. Never take two doses at once to make up for it. Check your leaflet, as some medicines are different.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2025-05-27.

Brands around the world

Products with Colestipol as the active ingredient. Names differ between countries.

Check your pack of Colestipol

Type the registration number on the pack, or scan it with your camera.

Or take photos of the pack
3 free checks left today Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Colestipol

What is Colestipol used for?

Since no drug is innocuous, strict attention should be paid to the indications and contraindications, particularly when selecting drugs for chronic long-term use. Colestipol hydrochloride tablets are indicated as adjunctive therapy to diet for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet. Generally, colestipol hydr (From the official U.S. FDA label.)

How do I take Colestipol?

Follow your prescription or the leaflet in your pack. The official label says: For adults, colestipol hydrochloride tablets are recommended in doses of 2 to 16 grams/day given once or in divided doses. The starting dose should be 2 grams once or twice daily. Dosage increases of 2 grams, once or twice daily should occur at 1-or 2-month intervals. Appropriate use of lipid profiles as per NCEP guidelines including LDL-C and triglycerides, is advised so that …

Should I take Colestipol with food?

If you have had swallowing problems or choking with food, liquids or other tablets or capsules in the past, you should discuss this with your doctor before taking colestipol hydrochloride tablets.

Do I need a prescription for Colestipol?

Usually yes. Colestipol is a prescription medicine in most countries. Rules differ by country.

What brands contain Colestipol?

Colestipol is sold under names such as Colestid, Colestipol Hydrochloride. Brand names differ between countries.

What are the side effects of Colestipol?

The official label lists: Gastrointestinal The most common adverse reactions are confined to the gastrointestinal tract. To achieve minimal GI disturbance with an optimal LDL-C lowering effect, a gradual increase of dosage starting with 2 grams, once or twice daily is recommended. Constipation is the major single complaint and at times is severe. Most instances of constipation are mild, transient, and c… Tell your doctor about any side effect that bothers you or does not go away.

Can children take Colestipol?

Safety and effectiveness in the pediatric population have not been established. Always use the dose for the child's age or weight on the pack or prescription.

Can I take Colestipol when pregnant or breastfeeding?

in Pregnancy Since colestipol hydrochloride is essentially not absorbed systemically (less than 0.17% of the dose), it is not expected to cause fetal harm when administered during pregnancy in recommended dosages. There are no adequate and well-controlled studies in pregnant women, and the known interference with absorption of fat-soluble vitamins may be detrimental even in the… Ask your doctor or midwife first.

Can I drink alcohol with Colestipol?

The official label says: , poorly controlled diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemias, obstructive liver disease, other drug therapy, alcoholism), should be excluded, and a lipid profile performed to assess total cholesterol, HDL-C, and triglycerides (TG).

What medicines interact with Colestipol?

Since colestipol hydrochloride is an anion exchange resin, it may have a strong affinity for anions other than the bile acids. In vitro studies have indicated that colestipol hydrochloride binds a number of drugs. Therefore, colestipol hydrochloride tablets may delay or reduce the absorption of concomitant oral medication. The interval between the administration of colestipol h… Use the free interaction checker before combining medicines.

What happens if I take too much Colestipol?

Overdosage of colestipol hydrochloride tablets has not been reported. Should overdosage occur, however, the chief potential harm would be obstruction of the gastrointestinal tract. The location of such potential obstruction, the degree of obstruction and the presence or absence of normal gut motilit… Get medical help right away.

How can I check that my Colestipol is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.