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Urea

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic.

Prescription medicine Topical Safety alerts on record

How to use Urea

What the official label says. If a doctor prescribed it, follow the prescription. Your pack's leaflet comes first if it is different.

Who it is for

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.

How to take it and how often
  • Apply Urea 40% to affected skin twice per day, or as directed by your physician
  • Rub in until completely absorbed
  • Apply to diseased or damaged nail(s) twice per day, or as directed by a physician
Talk to a doctor first if

Known hypersensitivity to any of the listed ingredients.

Warnings

For topical use only. Avoid contact with eyes, lips or mucous membranes.

Possible side effects

Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product. To report SUSPECTED ADVERSE REACTIONS, contact Method Pharmaceuticals, LLC at 1-877-250-3427; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

If you miss a dose

Take it when you remember, unless it is nearly time for the next dose. Then skip the missed one. Never take two doses at once to make up for it. Check your leaflet, as some medicines are different.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2026-01-15.

Registered products

United States (FDA)

Urea 40 PercentUREA 400 mg/g · Cream · Bryant Ranch Prepack
NDC 72162-1668Label
UreaUREA 39 g/100g · Cream · Bryant Ranch Prepack
NDC 63629-2036Label
Urea 39.5% With 2% Salicylic AcidUREA 39.5 g/100g, SALICYLIC ACID 2 g/100g · Cream · PureTek Corporation
NDC 59088-210Label
UreaUREA 40 g/100g · Lotion · Bryant Ranch Prepack
NDC 63629-2040Label
Milkbodylotion(HYDROXYMETHYL)UREA 100 mg/mL · Cream · Shengnan (Guangzhou) Cosmetics Co., LTD
NDC 84019-024Label

Nigeria (NAFDAC)

NAFDACDiafoot Cream B4-5375NAFDACMureal Tablet C4-1647NAFDACJawa Urea Cream A11-100081NAFDACJawa Urea Cream A11-100098NAFDACJawa Urea Cream A11-100099NAFDACSkinoRita Cream A4-100358NAFDACOxyurea Capsules A4-0852NAFDACDebridace Ointment B4-8268NAFDACHydroxyurea Capsule C4-1194NAFDACGlourea 500 Capsules C4-1790NAFDACHyxroxyurea 100mg Film Coated Tablet A4-100407NAFDACHydroxyurea 1000 mg Film Coated Tablets A4-100408

Other countries: check your pack's registration number and we point you to your regulator.

Safety alerts and recalls

C-UREA 40% BLADDER INSTILL, 30 mL vial, Rx only, Colonia Care Pharmacy, 515 Inman Ave., Suite A, Colonia, N.J. 07067U.S. FDA Class II
24 Jul 2019 · Colonia Care Pharmacy · TerminatedLack of Assurance of Sterility: product sterility cannot be guaranteed.
UREA 40% Cream, Rx only, Synergy RX, 4901 Morena Blvd # 504-A San Diego, CA 92117 (855) 792-6676U.S. FDA Class II
10 Feb 2017 · Synergy Rx · TerminatedLack of Assurance of Sterility: There are also CGMP Deviations.
Urea (50% Urea in a Cream Base), a) Net Wt. 5 oz (142 g), (NDC 42808-0200-05) b) Net Wt. 9 oz (225 g) (NDC 42808-0200-09), Rx Only, Manufactured in the U.S.A. for Exact-Rx Inc., MeU.S. FDA Class III
2 Jun 2016 · Exact-Rx Inc · TerminatedCrystallization; complaints received by the manufacturer of crystals forming in product
Remeven Cream, (50% Urea in a Cream Base), a) 5.0 oz (142 g) and b) 9.0 oz (255 g) tubes, Rx only, Manufactured by Sonar Products Inc, Carlstadt, NJ. Distributed by Stratus PharU.S. FDA Class III
26 May 2016 · Stratus Pharmaceuticals Inc · CompletedCrystallization; Complaints that cream appears to have crystallized

A recall usually affects certain batches only. Compare the lot number on your pack.

Check your pack of Urea

Or take photos of the pack
3 free checks left today Official sources: U.S. FDA · EMA (EU) · NAFDAC · WHO alerts

Questions about Urea

What is Urea used for?

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as (From the official U.S. FDA label.)

How do I take Urea?

Follow your prescription or the leaflet in your pack. The official label says: Apply Urea 40% to affected skin twice per day, or as directed by your physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.…

Do I need a prescription for Urea?

Usually yes. Urea is a prescription medicine in most countries. Rules differ by country.

What brands contain Urea?

Urea is sold under names such as Aluvea, Cem-urea, Hydrasyn25, Utopic, Kera-42, Kera Nail, Aqua Care, Aquaphilic With Urea. Brand names differ between countries.

How can I check that my Urea is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.