| Lopinavir and Ritonavir | Ritonavir | |
|---|---|---|
| What it is | Cytochrome P450 3A Inhibitor | Cytochrome P450 3A Inhibitor |
| Used for | Lopinavir and ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV1 infection in adults and pediatric patients 14 days and older. Limitations of Use: Genotypic or phenotypic testing and/or treatment history should gui… | Ritonavir tablets are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. Ritonavir tablets are HIV protease inhibitors indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection (… |
| Usual adult dose | Adults : Total recommended daily dosage is 800/200 mg given once or twice daily. | Adult patients: 600 mg twice-day with meals Pediatrics patients: The recommended twice daily dose for children greater than one month of age is based on body surface area and should not exceed 600 mg twice daily with meals Ritonavir oral solution should not be… |
| Children | Pediatric Patients (14 days and older) : Lopinavir and ritonavir once daily dosing regimen is not recommended in pediatric patients. | Not on the label |
| Prescription (U.S.) | Yes | Yes |
| Common side effects | The following adverse reactions are discussed in greater detail in other sections of the labeling. QT Interval Prolongation, PR Interval Prolongation [see Warnings and Precautions ( 5.5 , 5.6 )] Drug Interactions [see Warnings and… | The following adverse reactions are discussed in greater detail in other sections of the labeling. Drug Interactions [see Warnings and Precautions (5.1) ] Hepatotoxicity [see Warnings and Precautions (5.3) ] Pancreatitis [see Warn… |
| Serious warning | Not on the label | DRUG-DRUG INTERACTIONS LEADING TO POTENTIALLY SERIOUS AND/OR LIFE THREATENING REACTIONS Co-administration of ritonavir with several classes of drugs including sedative hypnotics, antiarrhythmics, or e… |
| Pregnancy | 8.1 Pregnancy Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to lopinavir and ritonavir during pregnancy. Physicians are encourage… | 8.1 Pregnancy Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ritonavir during pregnancy. Healthcare providers are encouraged to… |
From the official U.S. labels. Brands and strengths differ between countries.
The official labels mention them together: Co-administration of lopinavir and ritonavir can alter the plasma concentrations of other drugs and other drugs may alter the plasma concentrations of lopinavir. Ask a pharmacist before combining them.
Check them togetherLopinavir and Ritonavir is cytochrome P450 3A Inhibitor and Ritonavir is cytochrome P450 3A Inhibitor. Lopinavir and Ritonavir is used for: Lopinavir and ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV1 infection in adults and pediatric patients 14 days and older. Limitations of Use: Genotypic or phenotypic testing and/or treatment history should gui… Ritonavir is used for: Ritonavir tablets are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. Ritonavir tablets are HIV protease inhibitors indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection (…
The official labels mention them together: Co-administration of lopinavir and ritonavir can alter the plasma concentrations of other drugs and other drugs may alter the plasma concentrations of lopinavir. Ask a pharmacist before combining them.
It depends on what you are treating, your health and other medicines. Your doctor or pharmacist can tell you which one suits you; this page shows what each official label says.