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Diphenhydramine

Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose o.

Checked against the official label · Updated

Sold without prescription in some countries Oral Safety alerts on record

Diphenhydramine: quick answers

Used for
Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose or throat itchy, watery eyes.
Usual adult dose
Adults and children 12 years of age and over: Take 1 caplet every 4 to 6 hours while symptoms persist.
Children
Children under 12 years of age: ask a doctor.
Prescription
Sold without prescription in the United States; rules differ by country.

From the official label (Jan 2026). Your prescription and pharmacist come first.

How to use Diphenhydramine

What the official label says. If a doctor prescribed it, follow the prescription. Your pack's leaflet comes first if it is different.

Who it is for

Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose or throat itchy, watery eyes

How to take it and how often
  • Do not take more than directed
  • Adults and children 12 years of age and over: Take 1 caplet every 4 to 6 hours while symptoms persist
  • Do not take more than 6 caplets in 24 hours unless directed by a doctor
  • Children under 12 years of age: ask a doctor
While you are taking it

drowsiness may occur avoid alcoholic beverages alcohol, sedatives and tranquilizers may increase the drowsiness effect use caution when driving a motor vehicle or operating machinery excitability may occur, especially in children

Talk to a doctor first if

trouble urinating due to enlarged prostate gland glaucoma a breathing problem such as emphysema or chronic bronchitis

Warnings

Do not use with any other products containing diphenhydramine, even one used on skin

Pregnancy and breastfeeding

If pregnant or breast-feeding , ask a health professional before use.

How to store it

Keep out of reach of children.

If you miss a dose

Take it when you remember, unless it is nearly time for the next dose. Then skip the missed one. Never take two doses at once to make up for it. Check your leaflet, as some medicines are different.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2026-01-14.

How much Diphenhydramine costs

In other countries

Prices in other countries are not what you will pay where you live; they show how prices compare.

Registered products

United States (FDA)

Extra Strength Itch ReliefDIPHENHYDRAMINE HYDROCHLORIDE 20 mg/g, ZINC ACETATE 1 mg/g · Spray · Meijer Distribution Inc
NDC 79481-0598Label
Geri-dryl Allergy ReliefDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet, Coated · VerityRx
NDC 83939-0683Label
Multi Symptom Cold And Multi Symptom Nighttime Cold Childrens ChildrensKit · TARGET Corporation
NDC 11673-420Label
Diphenhydramine HydrochlorideDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1 · Capsule · Advance Pharmaceutical Inc.
NDC 17714-021Label
Ibuprofen PmIBUPROFEN 200 mg/1, DIPHENHYDRAMINE CITRATE 38 mg/1 · Tablet, Coated · KROGER COMPANY
NDC 30142-278Label

Nigeria (NAFDAC)

NAFDACEx-Coff A11-100047NAFDACDipar Syrup A11-1231NAFDACFimin Syrup A11-0426NAFDACVadilyn Syrup 04-4148NAFDACVadilix Syrup_ 04-4113NAFDACEmzor Para Night A11-0424NAFDACNalis Cough Syrup A11-100036NAFDACCleepain Tablets_ A11-0373NAFDACUgolab Baby Cough 04-4504NAFDACAvro Night Capsule A11-100083NAFDACD-Koff Expectorant 04-2751NAFDACExokuf Cough Syrup A11-100627

Other countries: check your pack's registration number and we point you to your regulator.

Safety alerts and recalls

Unisom, SleepMinis, Diphenhydramine HCl, Mini-Capsules, 25 mg, 60 Mini-Capsules bottles, Dist. by Chattem, Inc., P.O. Box 2219, Chattanooga, TN 37409-0219, USA, UPC 0 41167 00670 2U.S. FDA Class II
26 Mar 2025 · Chattem Inc · OngoingCGMP Deviations; detection of Nitrosamine Drug Substance-Related Impurities (NDSRI), N-nitroso-desmethyl-diphenhydramine (n-dph), above the FDA Recommended Intake Limit
Unisom, SleepMelts, Diphenhydramine HCl tablets, 25 mg, Nighttime Sleep-Aid, 4 x 8 blister packs per carton, Cherry flavor, Manufactured by Adare Pharmaceuticals, Inc., Dist. by ChU.S. FDA Class II
4 Mar 2025 · Chattem Inc · OngoingCGMP Deviations: Nitrosamine Drug Substance Related Issue impurity above the daily acceptable intake limit defined by the Food and Drug Administration.
Diphenhydramine HCl 25 mg, 1000 Capsules per bottle, Akron Pharma, Manufactured for: Akron Pharma, Inc., 373 RT US 46 W Building E., Suite 117, Fairfield, NJ 07004, NDC 71399-8028-U.S. FDA Class III
12 Dec 2024 · Akron Pharma, Inc. · OngoingLabeling: Not Elsewhere Classified: Tablets/Capsules imprinted with wrong ID.
Diphenhydramine HCl 50 mg, 1000 capsules per bottle, Akron Pharma, Manufactured for: Akron Pharma, Inc. 373 Route US 46, Building E, Suite 117, Fairfield, NJ 07004, NDC 71399-8026-U.S. FDA Class III
12 Dec 2024 · Akron Pharma, Inc. · OngoingLabeling: Not Elsewhere Classified: Tablets/Capsules imprinted with wrong ID.

A recall usually affects certain batches only. Compare the lot number on your pack.

Check your pack of Diphenhydramine

Type the registration number on the pack, or scan it with your camera.

Or take photos of the pack
3 free checks left today Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Diphenhydramine

What is Diphenhydramine used for?

Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose or throat itchy, watery eyes (From the official U.S. FDA label.)

How do I take Diphenhydramine?

Follow your prescription or the leaflet in your pack. The official label says: Do not take more than directed Adults and children 12 years of age and over: Take 1 caplet every 4 to 6 hours while symptoms persist do not take more than 6 caplets in 24 hours unless directed by a doctor Children under 12 years of age: ask a doctor…

Can I drive after taking Diphenhydramine?

Do not use with any other products containing diphenhydramine, even one used on skin drowsiness may occur avoid alcoholic beverages alcohol, sedatives and tranquilizers may increase the drowsiness effect use caution when driving a motor vehicle or operating ma…

Do I need a prescription for Diphenhydramine?

In many countries Diphenhydramine is sold without a prescription in some strengths. Rules differ by country, so ask a pharmacist.

What brands contain Diphenhydramine?

Diphenhydramine is sold under names such as Percogesic Reformulated Jan 2011, Wal-dryl, Compoz, Wal-dryl Childrens, Wal-dryl-d, Wal-dryl Allergy, Wal-som Maximum Strength, Nytol. Brand names differ between countries.

Can children take Diphenhydramine?

The label gives a separate dose by age: children 12 years. Check the pack or ask a pharmacist.

Can I take Diphenhydramine when pregnant or breastfeeding?

If pregnant or breast-feeding , ask a health professional before use. Ask your doctor or midwife first.

How can I check that my Diphenhydramine is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.