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Diphenhydramine

Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose o.

Checked against the official label · Updated

कुछ देशों में बिना प्रिस्क्रिप्शन के बेचा जाता है मुख संबंधी अलर्ट चालू

How to use Diphenhydramine

What the official label says. If a doctor prescribed it, follow the prescription. Your pack's leaflet comes first if it is different.

यह किसके लिए है

Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose or throat itchy, watery eyes

How to take it and how often
  • Do not take more than directed
  • Adults and children 12 years of age and over: Take 1 caplet every 4 to 6 hours while symptoms persist
  • Do not take more than 6 caplets in 24 hours unless directed by a doctor
  • Children under 12 years of age: ask a doctor
While you are taking it

drowsiness may occur avoid alcoholic beverages alcohol, sedatives and tranquilizers may increase the drowsiness effect use caution when driving a motor vehicle or operating machinery excitability may occur, especially in children

Talk to a doctor first if

trouble urinating due to enlarged prostate gland glaucoma a breathing problem such as emphysema or chronic bronchitis

Warnings

Do not use with any other products containing diphenhydramine, even one used on skin

Pregnancy and breastfeeding

If pregnant or breast-feeding , ask a health professional before use.

How to store it

Keep out of reach of children.

If you miss a dose

Take it when you remember, unless it is nearly time for the next dose. Then skip the missed one. Never take two doses at once to make up for it. Check your leaflet, as some medicines are different.

From the official U.S. FDA label for this active ingredient. Your pack may have a different strength, so always read its leaflet. If a doctor prescribed it, follow the prescription. Ask a pharmacist if you are unsure. Label dated 2026-01-14.

Registered products

United States (FDA)

Nighttime Sleep-aidDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet · NORTHEAST PHARMA
NDC 80136-785Label
Nighttime Sleep AidDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet · CHAIN DRUG MARKETING ASSOCIATION, INC.
NDC 83324-110Label
Up And Up Nighttime Flu And Severe Cold And Cough Nighttime Flu And Severe Cold And CoughACETAMINOPHEN 650 mg/1, DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1, PHENYLEPHRINE HYDROCHLORIDE 10 mg/1 · Powder, For Solution · Target Corporation
NDC 11673-113Label
Nighttime Sleep AidDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet, Coated · Health Pharma USA LLC
NDC 71679-110Label
Valumeds Pain Relief Pm Pain Reliever And Nighttime Sleep Aid Acetaminophen, Extra StrengthACETAMINOPHEN 500 mg/1, DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet · Cabinet Health P.B.C.
NDC 82725-1024Label

Nigeria (NAFDAC)

NAFDACEx-Coff A11-100047NAFDACDipar Syrup A11-1231NAFDACFimin Syrup A11-0426NAFDACVadilyn Syrup 04-4148NAFDACVadilix Syrup_ 04-4113NAFDACEmzor Para Night A11-0424NAFDACUgolab Baby Cough 04-4504NAFDACCleepain Tablets_ A11-0373NAFDACNalis Cough Syrup A11-100036NAFDACExokuf Cough Syrup A11-100627NAFDACKofmed Expectorant A4-8980NAFDACD-Koff Expectorant 04-2751

Other countries: check your pack's registration number and we point you to your regulator.

Safety alerts and recalls

Unisom, SleepMinis, Diphenhydramine HCl, Mini-Capsules, 25 mg, 60 Mini-Capsules bottles, Dist. by Chattem, Inc., P.O. Box 2219, Chattanooga, TN 37409-0219, USA, UPC 0 41167 00670 2U.S. FDA Class II
26 Mar 2025 · Chattem Inc · OngoingCGMP Deviations; detection of Nitrosamine Drug Substance-Related Impurities (NDSRI), N-nitroso-desmethyl-diphenhydramine (n-dph), above the FDA Recommended Intake Limit
Unisom, SleepMelts, Diphenhydramine HCl tablets, 25 mg, Nighttime Sleep-Aid, 4 x 8 blister packs per carton, Cherry flavor, Manufactured by Adare Pharmaceuticals, Inc., Dist. by ChU.S. FDA Class II
4 Mar 2025 · Chattem Inc · OngoingCGMP Deviations: Nitrosamine Drug Substance Related Issue impurity above the daily acceptable intake limit defined by the Food and Drug Administration.
Diphenhydramine HCl 25 mg, 1000 Capsules per bottle, Akron Pharma, Manufactured for: Akron Pharma, Inc., 373 RT US 46 W Building E., Suite 117, Fairfield, NJ 07004, NDC 71399-8028-U.S. FDA Class III
12 Dec 2024 · Akron Pharma, Inc. · OngoingLabeling: Not Elsewhere Classified: Tablets/Capsules imprinted with wrong ID.
Diphenhydramine HCl 50 mg, 1000 capsules per bottle, Akron Pharma, Manufactured for: Akron Pharma, Inc. 373 Route US 46, Building E, Suite 117, Fairfield, NJ 07004, NDC 71399-8026-U.S. FDA Class III
12 Dec 2024 · Akron Pharma, Inc. · OngoingLabeling: Not Elsewhere Classified: Tablets/Capsules imprinted with wrong ID.

A recall usually affects certain batches only. Compare the lot number on your pack.

Check your pack of Diphenhydramine

Type the registration number on the pack, or scan it with your camera.

Or take photos of the pack
3 free checks left today Official sources: U.S. FDA · EMA (EU) · Health Canada · WHO alerts

Questions about Diphenhydramine

What is Diphenhydramine used for?

Temporarily relieves these symptoms due to the common cold, hay fever, or other upper respiratory allergies: runny nose sneezing itching of the nose or throat itchy, watery eyes (From the official U.S. FDA label.)

How do I take Diphenhydramine?

Follow your prescription or the leaflet in your pack. The official label says: Do not take more than directed Adults and children 12 years of age and over: Take 1 caplet every 4 to 6 hours while symptoms persist do not take more than 6 caplets in 24 hours unless directed by a doctor Children under 12 years of age: ask a doctor…

Do I need a prescription for Diphenhydramine?

In many countries Diphenhydramine is sold without a prescription in some strengths. Rules differ by country, so ask a pharmacist.

What brands contain Diphenhydramine?

Diphenhydramine is sold under names such as Percogesic Reformulated Jan 2011, Wal-dryl, Compoz, Wal-dryl Childrens, Wal-dryl-d, Wal-dryl Allergy, Wal-som Maximum Strength, Nytol. Brand names differ between countries.

Can children take Diphenhydramine?

The label gives a separate dose by age: children 12 years. Check the pack or ask a pharmacist.

Can I take Diphenhydramine when pregnant or breastfeeding?

If pregnant or breast-feeding , ask a health professional before use. Ask your doctor or midwife first.

How can I check that my Diphenhydramine is genuine?

Scan the registration number on your pack with PillVera (NAFDAC number in Nigeria, NDC in the United States, DIN in Canada), check the expiry date and buy only from licensed pharmacies.

Sources

This page shows what official sources say, in plain words. It is not medical advice: your prescription and your doctor or pharmacist come first. Brand names, strengths and rules differ between countries.